Gamma Venom

Dr. Octopus tried defeating Spider-Man by creating a new Gamma Venom to defeat him but it failed.

History
Gamma Venom was a modified version of the Venom Symbiote to devour Spider-Man. Doctor Octopus sent Venom to attack the Agents of S.M.A.S.H. and merge with them. The symbiote went through various Hulks before he was taken out by the Hulks smashing a giant bell.